Valsartan Teva Drug Interactions

Caution should be exercised during concurrent use of potassium supplements, potassium sparing diuretics, salt substitutes containing potassium or other drugs that may increase the level of potassium (heparin, etc.) and frequent measurements of potassium levels should be performed.
Other antihypertensive agents can increase the antihypertensive effects of valsartan.
Combination with NSAIDs: When Angiotensin II antagonists are administered simultaneously with non-steroidal anti-inflammatory drugs (i.e. selective COX-2 inhibitors, acetylsalicylic acid (>3g/day) and non-selective NSAIDs), attenuation of the antihypertensive effect may occur.
As with ACE inhibitors, concomitant use of Angiotensin II antagonists and NSAIDs may lead to an increased risk of worsening of renal function, including possible acute renal failure, and an increase in serum potassium, especially in patients with poor pre-existing renal function. The combination should be administered with caution, especially in the elderly. Patients should be adequately hydrated and consideration should be given to monitoring renal function after initiation of concomitant therapy, and periodically thereafter.
Clinical trial data has shown that dual blockade of the RAAS through the combined use of ACE-inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function (including acute renal failure) compared to the use of a single RAAS-acting agent.
Reversible increases in lithium serum concentration and toxic effects have been reported during concomitant use of ACE-inhibitors. There is only limited experience with the concurrent use of valsartan and lithium. In case of concurrent use, monitoring serum levels of lithium is recommended.
No interactions of clinical relevance have been seen in association with the use of the following products commonly used for the treatment of patients with hypertension: cimetidine, warfarin, furosemide, digoxin, atenolol, indomethacin, hydrochlorothiazide, amlodipine, and glibenclamide.
Interaction studies have only been performed in adults.